Breast cancer type
Breast cancer type is categorized by whether it begins in the ducts or lobules, the organs responsible for breast milk production. Medullary carcinoma accounts for 15% of all breast cancer types. This breast cancer type represents 5% of all diagnosis. IPR015525 Breast cancer type 2 susceptibility protein Header EBIDatabasesInterPro Search Open in usermanual InterPro: " /> Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. The breast cancer type 2 susceptibility protein (BRCA2) is a breast tumour suppressor with a potential function in the cellular response to DNA damage. Some breast cancer types express one or more of these proteins on their cell surface, while others express none. Media Relations Contacts Online Press Kit Rumors, Myths, and Truths Glossary About the American Cancer Society Breastfeeding, Other Factors May Affect Risk of Breast Cancer TypeAtlanta 2008/08/25 -Factors such as age at menopause as well as a woman?s breastfeeding practices can influence her risk of developing certain types of breast cancer.
The investigators found that reproductive risk factors varied considerably by breast cancer subtype. Their analysis included 1,023 women with breast cancer whose cells express the estrogen and progesterone receptors (called luminal cancers), 39 women with HER2-overexpressing breast cancer, and 78 triple-negative cases (no expression of estrogen, progesterone, or HER2 receptors). The study also included 1,476 women without breast cancer. ? They added that additional studies on the causes of breast cancer subtypes are needed to better understand the biology of the disease. Learn more about our commitment to providing complete, accurate, and private breast cancer information. The study?s results suggest that there are distinct and separate hormonal risk factors associated with different subtypes of breast cancer. Women with what is referred to as "triple-negative" breast cancer are more likely than other women with breast cancer to experience a relapse, a new study by Canadian researchers shows. Despite having a high risk of early recurrence, the study indicates that triple-negative breast cancer patients who remain disease-free for eight years are unlikely to die of breast cancer and may be "cured" of their disease.
Breast Feeding Will Lowers Risk Of Breast Cancer
Breastfeeding for 6 months or longer was associated with a lower risk of luminal cancer as well as triple-negative cancer, a type that can be particularly aggressive and difficult to treat. Understanding the specific type of breast cancer can help you ask better questions and work with your physicians to get the best breast cancer treatments. For more information on the types and stages of breast cancer, watch Beyond the Shock®. Medullary carcinoma accounts for 15% of all breast cancer types. Infiltrating lobular carcinoma is a type of breast cancer that usually appears as a subtle thickening in the upper-outer quadrant of the breast. Making up about 2% of all breast cancer diagnosis, tubular carcinoma cells have a distinctive tubular structure when viewed under a microscope. Typically this type of breast cancer is found in women aged 50 and above. Inflammatory breast cancer is a rare and very aggressive type of breast cancer that causes the lymph vessels in the skin of the breast to become blocked.
Breast Cancer Risk
The study’s results suggest that there are distinct and separate hormonal risk factors associated with different subtypes of breast cancer. Amanda Phipps, a predoctoral research associate at the Fred Hutchinson Cancer Research Center in Seattle, and her colleagues conducted a study to better understand the specific risk factors for the subtypes of breast cancer, which are classified by expression of the estrogen receptor, the progesterone receptor, and the HER2 receptor. The investigators found that reproductive risk factors varied considerably by breast cancer subtype. Breastfeeding for 6 months or longer was associated with a lower risk of luminal cancer as well as triple-negative cancer, a type that can be particularly aggressive and difficult to treat. Both late age at menopause and use of estrogen plus progestin hormone therapy were associated with an increased risk of luminal disease. Finally, no differences in risks associated with number of children or the age when a woman first gave birth were observed by subtype. The study authors concluded that their results indicate that "certain reproductive factors may have a greater impact on risk of certain molecular subtypes of disease compared to others. Despite having a high risk of early recurrence, the study indicates that triple-negative breast cancer patients who remain disease-free for eight years are unlikely to die of breast cancer and may be "cured" of their disease. Insulin resistance, hyperinsulinemia, and changes in the signaling of growth hormones and steroid hormones associated with diabetes may affect the risk of breast cancer. Despite many proposed potential pathways, the mechanisms underlying an association between diabetes and breast cancer risk remain unclear, particularly because the 2 diseases share several risk factors, including obesity, a sedentary lifestyle, and possibly intake of saturated fat and refined carbohydrates, that may confound this association. Although the metabolic syndrome is closely related to diabetes and embraces additional components that might influence breast cancer risk, the role of the metabolic syndrome in breast carcinogenesis has not been studied and thus remains unknown.
For more info related to this subject and others please visit Breast Cancer Info
באמצעות: XTRA INFO
אודות המחבר:
Breast cancer type is categorized by whether it begins in the ducts or lobules, the organs responsible for breast milk production. Medullary carcinoma accounts for 15% of all breast cancer types. This breast cancer type represents 5% of all diagnosis. IPR015525 Breast cancer type 2 susceptibility protein Header EBIDatabasesInterPro Search Open in usermanual InterPro: " /> Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. The breast cancer type 2 susceptibility protein (BRCA2) is a breast tumour suppressor with a potential function in the cellular response to DNA damage. Some breast cancer types express one or more of these proteins on their cell surface, while others express none. Media Relations Contacts Online Press Kit Rumors, Myths, and Truths Glossary About the American Cancer Society Breastfeeding, Other Factors May Affect Risk of Breast Cancer TypeAtlanta 2008/08/25 -Factors such as age at menopause as well as a woman?s breastfeeding practices can influence her risk of developing certain types of breast cancer.
The investigators found that reproductive risk factors varied considerably by breast cancer subtype. Their analysis included 1,023 women with breast cancer whose cells express the estrogen and progesterone receptors (called luminal cancers), 39 women with HER2-overexpressing breast cancer, and 78 triple-negative cases (no expression of estrogen, progesterone, or HER2 receptors). The study also included 1,476 women without breast cancer. ? They added that additional studies on the causes of breast cancer subtypes are needed to better understand the biology of the disease. Learn more about our commitment to providing complete, accurate, and private breast cancer information. The study?s results suggest that there are distinct and separate hormonal risk factors associated with different subtypes of breast cancer. Women with what is referred to as "triple-negative" breast cancer are more likely than other women with breast cancer to experience a relapse, a new study by Canadian researchers shows. Despite having a high risk of early recurrence, the study indicates that triple-negative breast cancer patients who remain disease-free for eight years are unlikely to die of breast cancer and may be "cured" of their disease.
Breast Feeding Will Lowers Risk Of Breast Cancer
Breastfeeding for 6 months or longer was associated with a lower risk of luminal cancer as well as triple-negative cancer, a type that can be particularly aggressive and difficult to treat. Understanding the specific type of breast cancer can help you ask better questions and work with your physicians to get the best breast cancer treatments. For more information on the types and stages of breast cancer, watch Beyond the Shock®. Medullary carcinoma accounts for 15% of all breast cancer types. Infiltrating lobular carcinoma is a type of breast cancer that usually appears as a subtle thickening in the upper-outer quadrant of the breast. Making up about 2% of all breast cancer diagnosis, tubular carcinoma cells have a distinctive tubular structure when viewed under a microscope. Typically this type of breast cancer is found in women aged 50 and above. Inflammatory breast cancer is a rare and very aggressive type of breast cancer that causes the lymph vessels in the skin of the breast to become blocked.
Breast Cancer Risk
The study’s results suggest that there are distinct and separate hormonal risk factors associated with different subtypes of breast cancer. Amanda Phipps, a predoctoral research associate at the Fred Hutchinson Cancer Research Center in Seattle, and her colleagues conducted a study to better understand the specific risk factors for the subtypes of breast cancer, which are classified by expression of the estrogen receptor, the progesterone receptor, and the HER2 receptor. The investigators found that reproductive risk factors varied considerably by breast cancer subtype. Breastfeeding for 6 months or longer was associated with a lower risk of luminal cancer as well as triple-negative cancer, a type that can be particularly aggressive and difficult to treat. Both late age at menopause and use of estrogen plus progestin hormone therapy were associated with an increased risk of luminal disease. Finally, no differences in risks associated with number of children or the age when a woman first gave birth were observed by subtype. The study authors concluded that their results indicate that "certain reproductive factors may have a greater impact on risk of certain molecular subtypes of disease compared to others. Despite having a high risk of early recurrence, the study indicates that triple-negative breast cancer patients who remain disease-free for eight years are unlikely to die of breast cancer and may be "cured" of their disease. Insulin resistance, hyperinsulinemia, and changes in the signaling of growth hormones and steroid hormones associated with diabetes may affect the risk of breast cancer. Despite many proposed potential pathways, the mechanisms underlying an association between diabetes and breast cancer risk remain unclear, particularly because the 2 diseases share several risk factors, including obesity, a sedentary lifestyle, and possibly intake of saturated fat and refined carbohydrates, that may confound this association. Although the metabolic syndrome is closely related to diabetes and embraces additional components that might influence breast cancer risk, the role of the metabolic syndrome in breast carcinogenesis has not been studied and thus remains unknown.
For more info related to this subject and others please visit Breast Cancer Info
באמצעות: XTRA INFO
אודות המחבר:
Breast Cancer Info
AN ARTICLE ON CANCER
What is cancer?
Cancer is the general term used for diseases in which normal cells separate without any control thus involving other tissues. Cancer cells can also spread to various parts of the body through the blood and lymph system.
Wild cell growth turns into cancer when it is exposed to carcinogens (סרטן- causing substance) genetic defects, or viruses. A tumour is formed when cancer cells multiply large masses of tissue. In some cases tumours limit themselves to one spot in the body; some can be removed by surgery. These kinds of tumours may cause little harm and is termed benign. Hostile tumours are called malignant. The study of cancer is called oncology.
Causes of Cancer
People get lung cancer most of the time from smoking tobacco which is said to have carcinogenic substance mainly known as tobacco smoke. Some carcinogens include certain chemicals, the Sun’s ultraviolet light, and radiation. Cancer can be formed by several viruses by altering the DNA of a host cell and converting the cell’s normal genes into cancer – causing genes, or oncogenes. Genetic factors – such as chromosomal abnormalities or the inheritance of faulty genes from a parent of fore parent. This could most likely cause these persons who inherit these genes can end up having cancer. People that are Down syndrome, a chromosomal abnormality are susceptible to leukaemia.
How is cancer formed?
When a normal cell transforms into a cancer cell the genetic material (deoxyribonucleic acid or DNA) of a cell is changed, or mutated. Tumours don’t form over night they formed over decades or a certain amount of years, because of this it is very susceptible to formed into a cancer cell as time goes along. Most cancer occurs after the age of fifty, yet some are detected earlier in life, it varies.
Different types of cancer
It has been accessed that there are over more than 200 different types of cancers. They are named after the tissue or the organ they begin to form. The term Leukemia refers to cancer of white blood cells (can be also called leukocytes). Melanomas are cancers that begin in melanocytes (skin pigmentation.
Names of Cancers
Lung Cancer
Bladder Cancer
Colon and Rectal Cancer
סרטן השד
Endometrial Cancer
Kidney (Renal Cell) סרטן
Non- Hodgkin Lymphoma Pancreatic Cancer
Skin Cancer
Non-melanoma thyroid Cancer
Prostrate Cancer
Leukemia
Bladder Cancer
Bone Cancer
Bile Duct Cancer
Brain Tumour
Appendix Cancer
Adrenocortical Carcinoma
Cervical cancer
Childhood cancer
Eye Cancer
Gall bladder Cancer
Kidney Cancer
Lip and oral Cancer
סרטן הכבד
Mouth Cancer
Rectal Cancer
Salivary Cancer
Urethral Cancer
Vaginal Cancer
Vulvar Cancer
Treatments for cancer
Oncologists have been using Chemotherapy, or drug therapy to help cancer patience around the world. When cancer spreads to different parts of the body chemotherapy is used to help treat the cancer, before it gets worst. The immune system is weak when cancer spreads through the body. Therefore a treatment name immune enhancing drugs or antibodies are also used to help build back up the immune system and to destroy abnormal cells. There has been an anticancer drug that kills cancer cells while leaving the good ones alive. This drug was introduced in the spring of 2001. The drug, Gleevec has proven to work very strongly against chronic myelogenous leukaemia, leukaemia is one of the four main types of blood cancer.
How can u prevent cancer?
Cancer can be prevented by doing the following:
¬For all smokers the only way that you can avoid yourself from getting lung cancer is to stop smoking.
¬Try not to be in the sun for lengthy periods, too much exposure to the sun can cause cancer
¬Lessen your high- fat diets
¬Avoid alcohol as much as possible
¬Unsafe sex
¬Other Carcinogens could prevent more than 80% of all cancer cases.
¬Do yearly testing; this would detect it in the early stage if you are tested positive, early treatment can be taken.
The following are various tests than can be taken to see if you have cancer.
Skin Cancer: Skin examination this is done by the naked eye of the doctor. If any area may look suspicious then biopsy is done and under the microscope cancer cells are examined
Prostate Cancer:
· Digital Rectal Examination: Prostrate is examined by a doctor using his/her finger from the lower part from the rectum. When you reach fifty years it must be done at least once a year. If there was any sign before that you may have prostrate then do a test once every year even though you may be under forty
סרטן השד:
· Breast Self Examination: when you reach twenty years of age, this examination must be taken once every month.
· Clinical Breast Examination: the breasts and regions under the arms should be examined also, between the ages of 20 and 40 שנים. Once every three years this examination should be carried out, and once every year after the age of forty.
· Mammogram: Imaging of the breasts with X rays. It must be done once every year after 40 years of age.
An illustration of how a mammogram is done
Lung Cancer:
Chest X-ray: It is imaging of organs and bones in chest with X-ray. Especially if you are a smoker you should do chest x –rays at least twice a year.
Colorectal Cancer:
· Fecal Occult Blood Test: Blood in stool which can be seen only under microscope is examined. It must be done once every year after 50 years of age.
Why cancer has and is becoming more prevalent
Over the last generation there has been vast difference between the way we use to live and how we are now living. I can almost say that we live in a different world. Technology has been increased by a large percentage. Smelter plants, environmental chemical, polluted air, microwaves, computers, utensils and a lot of foods are said to be cancerous to us. Meats that are harmonized (e.g. chicken), plants, vegetables, fruits etc. these are all things that should make us healthy, but instead it can be deadly to us. Because of the amount of hormones that are being injected into them, plants and trees are being sprayed with insecticide, fertilizers as though these liquids are water. Then they are being sold to groceries, farmers etc, for us to buy and eat.
Is there any cure for cancer?
Since cancer has been detected, no cure solution has ever been introduced. Various anti–cancer tablets and chemotherapy was put in place in order to control cancer cells. סרטן, AIDS and Sugar diabetes are the three major sicknesses that have no cure. Although there are things out there to help cancer. It is proven that more and more people are getting cancer. Women have become prone to Breast cancer for the past 3o years. United States had even poured out $30 billion to help find a solution to cure cancer.
באמצעות: Abigail J. Chandler
אודות המחבר:
What is cancer?
Cancer is the general term used for diseases in which normal cells separate without any control thus involving other tissues. Cancer cells can also spread to various parts of the body through the blood and lymph system.
Wild cell growth turns into cancer when it is exposed to carcinogens (סרטן- causing substance) genetic defects, or viruses. A tumour is formed when cancer cells multiply large masses of tissue. In some cases tumours limit themselves to one spot in the body; some can be removed by surgery. These kinds of tumours may cause little harm and is termed benign. Hostile tumours are called malignant. The study of cancer is called oncology.
Causes of Cancer
People get lung cancer most of the time from smoking tobacco which is said to have carcinogenic substance mainly known as tobacco smoke. Some carcinogens include certain chemicals, the Sun’s ultraviolet light, and radiation. Cancer can be formed by several viruses by altering the DNA of a host cell and converting the cell’s normal genes into cancer – causing genes, or oncogenes. Genetic factors – such as chromosomal abnormalities or the inheritance of faulty genes from a parent of fore parent. This could most likely cause these persons who inherit these genes can end up having cancer. People that are Down syndrome, a chromosomal abnormality are susceptible to leukaemia.
How is cancer formed?
When a normal cell transforms into a cancer cell the genetic material (deoxyribonucleic acid or DNA) of a cell is changed, or mutated. Tumours don’t form over night they formed over decades or a certain amount of years, because of this it is very susceptible to formed into a cancer cell as time goes along. Most cancer occurs after the age of fifty, yet some are detected earlier in life, it varies.
Different types of cancer
It has been accessed that there are over more than 200 different types of cancers. They are named after the tissue or the organ they begin to form. The term Leukemia refers to cancer of white blood cells (can be also called leukocytes). Melanomas are cancers that begin in melanocytes (skin pigmentation.
Names of Cancers
Lung Cancer
Bladder Cancer
Colon and Rectal Cancer
סרטן השד
Endometrial Cancer
Kidney (Renal Cell) סרטן
Non- Hodgkin Lymphoma Pancreatic Cancer
Skin Cancer
Non-melanoma thyroid Cancer
Prostrate Cancer
Leukemia
Bladder Cancer
Bone Cancer
Bile Duct Cancer
Brain Tumour
Appendix Cancer
Adrenocortical Carcinoma
Cervical cancer
Childhood cancer
Eye Cancer
Gall bladder Cancer
Kidney Cancer
Lip and oral Cancer
סרטן הכבד
Mouth Cancer
Rectal Cancer
Salivary Cancer
Urethral Cancer
Vaginal Cancer
Vulvar Cancer
Treatments for cancer
Oncologists have been using Chemotherapy, or drug therapy to help cancer patience around the world. When cancer spreads to different parts of the body chemotherapy is used to help treat the cancer, before it gets worst. The immune system is weak when cancer spreads through the body. Therefore a treatment name immune enhancing drugs or antibodies are also used to help build back up the immune system and to destroy abnormal cells. There has been an anticancer drug that kills cancer cells while leaving the good ones alive. This drug was introduced in the spring of 2001. The drug, Gleevec has proven to work very strongly against chronic myelogenous leukaemia, leukaemia is one of the four main types of blood cancer.
How can u prevent cancer?
Cancer can be prevented by doing the following:
¬For all smokers the only way that you can avoid yourself from getting lung cancer is to stop smoking.
¬Try not to be in the sun for lengthy periods, too much exposure to the sun can cause cancer
¬Lessen your high- fat diets
¬Avoid alcohol as much as possible
¬Unsafe sex
¬Other Carcinogens could prevent more than 80% of all cancer cases.
¬Do yearly testing; this would detect it in the early stage if you are tested positive, early treatment can be taken.
The following are various tests than can be taken to see if you have cancer.
Skin Cancer: Skin examination this is done by the naked eye of the doctor. If any area may look suspicious then biopsy is done and under the microscope cancer cells are examined
Prostate Cancer:
· Digital Rectal Examination: Prostrate is examined by a doctor using his/her finger from the lower part from the rectum. When you reach fifty years it must be done at least once a year. If there was any sign before that you may have prostrate then do a test once every year even though you may be under forty
סרטן השד:
· Breast Self Examination: when you reach twenty years of age, this examination must be taken once every month.
· Clinical Breast Examination: the breasts and regions under the arms should be examined also, between the ages of 20 and 40 שנים. Once every three years this examination should be carried out, and once every year after the age of forty.
· Mammogram: Imaging of the breasts with X rays. It must be done once every year after 40 years of age.
An illustration of how a mammogram is done
Lung Cancer:
Chest X-ray: It is imaging of organs and bones in chest with X-ray. Especially if you are a smoker you should do chest x –rays at least twice a year.
Colorectal Cancer:
· Fecal Occult Blood Test: Blood in stool which can be seen only under microscope is examined. It must be done once every year after 50 years of age.
Why cancer has and is becoming more prevalent
Over the last generation there has been vast difference between the way we use to live and how we are now living. I can almost say that we live in a different world. Technology has been increased by a large percentage. Smelter plants, environmental chemical, polluted air, microwaves, computers, utensils and a lot of foods are said to be cancerous to us. Meats that are harmonized (e.g. chicken), plants, vegetables, fruits etc. these are all things that should make us healthy, but instead it can be deadly to us. Because of the amount of hormones that are being injected into them, plants and trees are being sprayed with insecticide, fertilizers as though these liquids are water. Then they are being sold to groceries, farmers etc, for us to buy and eat.
Is there any cure for cancer?
Since cancer has been detected, no cure solution has ever been introduced. Various anti–cancer tablets and chemotherapy was put in place in order to control cancer cells. סרטן, AIDS and Sugar diabetes are the three major sicknesses that have no cure. Although there are things out there to help cancer. It is proven that more and more people are getting cancer. Women have become prone to Breast cancer for the past 3o years. United States had even poured out $30 billion to help find a solution to cure cancer.
באמצעות: Abigail J. Chandler
אודות המחבר:
D.O.B. : January 4th ,1988
MichellePhan asked:
You read a detailed description here www.xanga.com music Late Night Alumni: Sunrise Comes
UK Blogger
There is nothing that puts more fear in people than a diagnosis of Cancer. Statistically speaking, we now have one in two chances (male) or one in three chances (female) of getting cancer before the end of our life (American Cancer Society statistics for the year 2003). At the beginning of the 20th century, statistics gave us one in 500 chances of getting cancer.
All cancers considered, if you have a primary cancer (in one location only) the most optimistic statistics only give you 28% chances of recovery. If you have metastatic cancer (in more than one location) then your chances of recovery are 0.1% or in other words, one chance in one thousand to recover - (statistics from Dr Philip Binzel book “Alive and Well” published by American Media).
The news is bleak to say the least. However, as we will see later on, this need not be the case.
Ever since I can remember, I have read newspaper articles, heard claims on TV or radio, reporting new “wonder” cures on the war against cancer. Victory against this terrible disease was, according to these reports, just around the corner. Why is it then that so many people are still dying from this disease? Are the 600 UK cancer charities (The largest UK charities being Imperial Cancer Research Fund, Cancer Research Campaign and Institute of Cancer Research) lying to us?
The “American Cancer Society” is the richest charity in the world. All debts paid, it would still have half a billion dollars in the bank!
Linus Pauling, the winner of two Nobel prizes, seemed to think so when he said: “Everyone should know that most cancer research is largely a fraud and that the major cancer research organisations are derelict in their duties to the people who support them.”
What is Cancer?
Modern researchers have for many years been exploring the virus connection at a cost of billions of dollars and pounds. The pitiful result is that “no cancer that was incurable 25 years ago is curable today and that, for the most common cancers that kills 90% of patients today chemotherapy is no better than snake oil” (The Cancer Handbook. What Doctors don’t tell you publication. By Lynne Taggart).
When you are diagnosed with cancer, what the doctor is really saying is that you have one or several tumours in your body and that at least one of the tumours contains some cancer cells. They see the tumours as the enemy that has to be fought and destroyed and all their efforts are directed against eradicating the tumours.
What is a tumour though? A tumour is only a symptom; it shows that something has gone wrong in your body and that your immune system is no longer available to fight it. Many researchers claim that we all have tumours in our body and that several times in our life we get cancer. However, we do not all die from cancer. The reason is that our body’s defence mechanism spring into action when a tumour is formed and gets rid of it or at least neutralises it. If cancer cells are beginning to form, these are killed off by our immune system and all is back to normal.
However if for some reason our immune system is severely deficient and we are unable to fight off the formation of the cancerous cells, then disease spreads.
What needs to be done to fight the tumour is not so much to remove it (surgery), burn it (radiation) or poison it (chemotherapy) as all these will weaken our immune system (damaging both our liver and kidneys to a point where it is difficult for our body to fight off any health problem). But to find out why the tumour formed in the first place and remove the cause.
Fighting it according to Dr Binzel is no good, our body now has in its memory the recipe to form tumours and uses the negative ingredients we feed it with to form new tumours and it will rarely stop doing so unless we remove the cause. The lack of positive ingredients (Vitamins, minerals and essential enzymes) to fight off the tumour is just as important.
Let me compare this reasoning with the simple example of a tooth infection. There is no point in taking painkillers to fix the tooth. I grant you that they will probably relieve the pain but I profess that they will not cure the tooth. What needs to be done is to get rid of the infection with antibiotics or have the tooth removed.
What do cancer cells feed on?
Several factors such as diet, negative emotions/ stress and environmental toxins are usually responsible for the development of cancer. Dietary speaking, cancer cells need food to survive. Dr Otto Warburg received the Nobel Prize for scientifically proving that cancer feed from the fermentation of sugar:
“in cancer cells [the feeding] is replaced by an energy-yielding reaction of the lowest living forms; namely, a fermentation of glucose” (quoted in prevention - May 1968).
According to Macrobiotic medicine theory, cancer cells also feed on animal protein (all types of meat, especially chicken but also very much on dairy, eggs etc..)
Detecting cancer
Currently, surgeons often perform a biopsy when cancer is suspected. A biopsy is a way of extracting a quantity of matter from a tumour and test it to see if it is cancerous. The problem with this method is that if the tumour is cancerous and the tumour is punctured, there is a definite risk that the cancerous liquid will spread to surrounding cells and spread the cancer around the body (Roger Delin - medical analyst - Philippines.
Breast cancer is often diagnosed using a mammogram. The main manufacturer of mammographic equipment is a company called “Smarlight Mammographics”. They state: “We expected error rates to be around 30%, but the wide range of results (10%-90%) was an eye-opener.” Amazing admission from the largest manufacturer of what is considered as the ultimate test to detect breast cancer. Unbelievable !
It is interesting to learn that autopsies have shown that many undetected cancers were present in the body of people who died from other causes. This makes a mockery of medical statistics and confirms that in fact a substantial number of cancers are never detected and do not obligatorily cause death.
A Swedish study has revealed that 15% of major cancers were not revealed before death and around half were of a type normally considered fatal (נ"צ: wddty).
Modern approach and progress on cancer
The modern approach to treat cancer is surgery, radiation, chemotherapy, hormones and immunotherapy. The percentage of oncologists (cancer doctors) who would not participate in chemotherapy trials is an alarming 75% (due to its toxicity). (John Robbins
באמצעות: Patrick Hamouy
אודות המחבר:
All cancers considered, if you have a primary cancer (in one location only) the most optimistic statistics only give you 28% chances of recovery. If you have metastatic cancer (in more than one location) then your chances of recovery are 0.1% or in other words, one chance in one thousand to recover - (statistics from Dr Philip Binzel book “Alive and Well” published by American Media).
The news is bleak to say the least. However, as we will see later on, this need not be the case.
Ever since I can remember, I have read newspaper articles, heard claims on TV or radio, reporting new “wonder” cures on the war against cancer. Victory against this terrible disease was, according to these reports, just around the corner. Why is it then that so many people are still dying from this disease? Are the 600 UK cancer charities (The largest UK charities being Imperial Cancer Research Fund, Cancer Research Campaign and Institute of Cancer Research) lying to us?
The “American Cancer Society” is the richest charity in the world. All debts paid, it would still have half a billion dollars in the bank!
Linus Pauling, the winner of two Nobel prizes, seemed to think so when he said: “Everyone should know that most cancer research is largely a fraud and that the major cancer research organisations are derelict in their duties to the people who support them.”
What is Cancer?
Modern researchers have for many years been exploring the virus connection at a cost of billions of dollars and pounds. The pitiful result is that “no cancer that was incurable 25 years ago is curable today and that, for the most common cancers that kills 90% of patients today chemotherapy is no better than snake oil” (The Cancer Handbook. What Doctors don’t tell you publication. By Lynne Taggart).
When you are diagnosed with cancer, what the doctor is really saying is that you have one or several tumours in your body and that at least one of the tumours contains some cancer cells. They see the tumours as the enemy that has to be fought and destroyed and all their efforts are directed against eradicating the tumours.
What is a tumour though? A tumour is only a symptom; it shows that something has gone wrong in your body and that your immune system is no longer available to fight it. Many researchers claim that we all have tumours in our body and that several times in our life we get cancer. However, we do not all die from cancer. The reason is that our body’s defence mechanism spring into action when a tumour is formed and gets rid of it or at least neutralises it. If cancer cells are beginning to form, these are killed off by our immune system and all is back to normal.
However if for some reason our immune system is severely deficient and we are unable to fight off the formation of the cancerous cells, then disease spreads.
What needs to be done to fight the tumour is not so much to remove it (surgery), burn it (radiation) or poison it (chemotherapy) as all these will weaken our immune system (damaging both our liver and kidneys to a point where it is difficult for our body to fight off any health problem). But to find out why the tumour formed in the first place and remove the cause.
Fighting it according to Dr Binzel is no good, our body now has in its memory the recipe to form tumours and uses the negative ingredients we feed it with to form new tumours and it will rarely stop doing so unless we remove the cause. The lack of positive ingredients (Vitamins, minerals and essential enzymes) to fight off the tumour is just as important.
Let me compare this reasoning with the simple example of a tooth infection. There is no point in taking painkillers to fix the tooth. I grant you that they will probably relieve the pain but I profess that they will not cure the tooth. What needs to be done is to get rid of the infection with antibiotics or have the tooth removed.
What do cancer cells feed on?
Several factors such as diet, negative emotions/ stress and environmental toxins are usually responsible for the development of cancer. Dietary speaking, cancer cells need food to survive. Dr Otto Warburg received the Nobel Prize for scientifically proving that cancer feed from the fermentation of sugar:
“in cancer cells [the feeding] is replaced by an energy-yielding reaction of the lowest living forms; namely, a fermentation of glucose” (quoted in prevention - May 1968).
According to Macrobiotic medicine theory, cancer cells also feed on animal protein (all types of meat, especially chicken but also very much on dairy, eggs etc..)
Detecting cancer
Currently, surgeons often perform a biopsy when cancer is suspected. A biopsy is a way of extracting a quantity of matter from a tumour and test it to see if it is cancerous. The problem with this method is that if the tumour is cancerous and the tumour is punctured, there is a definite risk that the cancerous liquid will spread to surrounding cells and spread the cancer around the body (Roger Delin - medical analyst - Philippines.
Breast cancer is often diagnosed using a mammogram. The main manufacturer of mammographic equipment is a company called “Smarlight Mammographics”. They state: “We expected error rates to be around 30%, but the wide range of results (10%-90%) was an eye-opener.” Amazing admission from the largest manufacturer of what is considered as the ultimate test to detect breast cancer. Unbelievable !
It is interesting to learn that autopsies have shown that many undetected cancers were present in the body of people who died from other causes. This makes a mockery of medical statistics and confirms that in fact a substantial number of cancers are never detected and do not obligatorily cause death.
A Swedish study has revealed that 15% of major cancers were not revealed before death and around half were of a type normally considered fatal (נ"צ: wddty).
Modern approach and progress on cancer
The modern approach to treat cancer is surgery, radiation, chemotherapy, hormones and immunotherapy. The percentage of oncologists (cancer doctors) who would not participate in chemotherapy trials is an alarming 75% (due to its toxicity). (John Robbins
באמצעות: Patrick Hamouy
אודות המחבר:
Patrick Hamouy runs a school of Alternative Therapies in the UK. He teaches Reiki Healing, Indian Head Massage, Emotional Freedom Therapy (EFT), Anatomy & Physiology, Oriental Diagnosis & Psychic Development. He sees customers for consultations.in Macrobiotic, Emotional Freedom Therapy (EFT) and Removal of toxic products from the home environment Full information on his web site at: http://www.therapies.com
Using known risk factors for breast cancer, mathematical models can be developed to help answer important questions. These mathematical models are useful tools for researchers and for patients as follows:
1. Research on risk factors - The Claus risk assessment model was used to discover the subpopulation of people who had an autosomal dominant genetic allele that increased their risk from 10% to 92%. This led to the discovery of the BRCA genes associated with breast, ovarian, and prostate cancer. 2. Clinical trial eligibility - The Gail risk assessment model was developed to help researchers determine who to enroll in the NSAPB Breast Cancer Prevention Trials
where chemoprevention was shown to reduce breast cancer risk.
3. Guidelines for doing BRCA testing - BRCA testing is very expensive and practically worthless if done on everyone (because it is so rare to be homozygous for BRCA1 or BRCA2). Mathematical models such as the BRCAPRO, BOADICEA, and Tyrer-Cuzick models can help determine what patients should undergo BRCA testing. The decision for testing is usually made when one of these models predicts a 10% or greater chance that there is a mutation of the BRCA1, Kick2, or both genes. 4. Guidelines for doing MRI screening for breast cancer - MRI screening for breast cancer is not a cost effective screening test for the general population, but in specific groups, there are clear cut reasons to do so. In general, screening MRI is recommended for women with 20-25% or greater lifetime risk of breast cancer. The BRCAPRO and Tyrer-Cuzick models have been used to help make clinical decisions about ordering MRIs for breast cancer screening. 5. Guidelines for breast cancer therapy - The Gail model is used clinically to help
determine who should be put on tamoxifen or raloxifene for chemoprevention. Other models have been used to help make decisions about breast cancer risk reduction with prophylactic mastectomy.
For these reasons, it is important to understand these models. These models are collectively refered to as “risk assessment tools”. The following paragraphs summarize the most popular and most widely used risk assessment tools. Keep in mind that none of these risk assessment tools apply to breast cancer survivors. No mathematical model has been widely accepted to determine cancer risk in cancer survivors.
General Risk Assessment Tools
Gail Model: The Gail model is a validated risk-assessment model that focuses primarily on nonhereditary risk factors, with limited information on family history. It was developed by scientists at the National Cancer Institute and the National Surgical Adjuvant Breast and Bowel Project (NSABP) to assist health care providers in discussing breast cancer risk to determine their eligibility for the Breast Cancer Prevention Trial. The tool allows one to project a woman’s individual estimate of breast cancer risk over a five-year period of time and over her lifetime. It also compares the woman’s risk calculation with the average risk for a woman of the same age. The Gail Model is an on-line quiz that has 13 questions and is interactive. This calculator is based on published risk statistics and methods gathered from peer-reviewed journals, and has been extensively tested for its validity.
The major limitation of the Gail model is the inclusion of only first-degree relatives, which results in underestimating risk in the 50% of families with cancer in the paternal lineage and also takes no account of the age of onset of breast cancer. It may underestimate risk in certain groups, such as obese patients.
National Cancer Institute Model: The NCI risk assessment tool is essentially a simplified Gail Model that also factors in race. Race is a factor in determining breast cancer risk but is excluded when determining eligibility for clinical trials. This tool is probably the most popular risk assessment tool available to the public as an on-line, interactive risk calculator. The on-line quiz is a shorter, nine-point questionnaire that includes multiple factors, giving a woman her future five-year risk of breast cancer and her lifetime risk of breast cancer.
The NCI tool does not account for a lot of risk factors that can be modified. For this reason, it is difficult to use this test as a motivation tool to show people how lifestyle can alter their risk of breast cancer. It also cannot be used in breast cancer survivors, in patients with DCIS, LCIS, or people who carry one of the BRCA genes.
BRCAPRO model: This is a statistical model available as a computer program that uses two different algorithms to evaluate family history and helps a doctor determine the likelihood of finding either a BRCA1 mutation or a BRCA2 mutation in a family. The results of this can be used to determine if BRCA testing is indicated. This is very useful in light of the high cost of BRCA testing ($3,000). None of the nonhereditary risk factors can yet be incorporated into the model, however. In a comparison of four different methods for estimating breast cancer risk in patients with a family history of breast cancer, the BRCAPRO model was the least accurate. It predicted only 49% of the breast cancers that actually occurred in the screened group of patients with a family history of breast cancer.
Harvard Center for Cancer Prevention Risk Assessment Tool: This is another breast cancer risk assessment tool that includes more lifestyle factors than the NCI or Gail Model tools. It has not been studied as extensively as the Gail Model or the simplified NCI model, but it is promising in that it includes many lifestyle factors that people can do to modify their risk of developing cancer. It is also an on-line questionnaire that can be used by both women and men to estimate their breast cancer risk.
Making all this practical
Now after a thorough and confusing discussion of all these statistical models, it’s time to make all this information practical. What is the best way to help a patient accurately assess her risk of breast cancer and if possible, show her what positive factors are reducing her risk and what negative factors can be changed to reduce her risk? If possible, it would also be great to show the patient the value and indications for testing, imaging, chemoprevention, and in some cases surgery. A discussion of the practical aspect of each of these is addressed in a Q & A format below:
Q: What (free) online programs can be used to help a patient assess their risk of breast cancer?
A: Several of the risk assessment tools mentioned above can be accessed for free by the public. Here are the tests and their websites:
1. Your Disease Risk - English version: http://www.diseaseriskindex.harvard.edu
This is a great interactive questionnaire that calculates five-year and lifetime risk of breast cancer developed by the Harvard Center for Cancer Prevention and made public online in 2000. In 2005, they launched the Spanish version of the site, “Cuidar de su Salud”. The risk calculator includes lifestyle factors such as weight, dietary vegetables, alcohol intake, as well as Jewish ethnicity. It does not include other ethnicities, however, and is not accurate for BRCA mutation carriers or breast cancer survivors. Despite these issues, this is by far the best free online risk calculator since it is very interactive and gives you a personalized description of your risk in the form of a colored bar graph, which they can electronically manipulate to experience “virtual” risk reduction. The bar graph is a seven-level scale that compares users to a typical man or woman your age. Users learn where to focus their prevention efforts and how to make lifestyle changes by “clicking on” personalized strategies. With each click, the bar graph shrinks, and the user watches his/her predicted risk drop. This is a great concept to motivate people to participate and comply with lifestyle modification measures.
2. The NCI Risk Assessment Tool -regular web: http://www.cancer.gov/bcrisktool
This is the easy to use, on-line questionnaire based on a modified Gail model that also includes ethnicity. It does not factor in a personal history of breast cancer, DCIS, or LCIS. It does not account for other factors such as BRCA status, hormonal replacement therapy, lifestyle factors, breast feeding, הפסקת וסת, or mammographic density. Despite these issues, it is a very useful tool that gives a woman her five-year and lifetime risk of breast cancer. It is the only risk assessment tool that can be used via mobile handheld devices (any type). A version of this can be downloaded for PDAs with Windows Pocket PC operating system as well.
Q: What programs can be used to help a doctor make decisions about ordering a breast MRI?
A: The American Cancer Society has developed some very good guidelines for breast cancer screening with MRI. It should be emphasized that MRI is an adjunct to mammography, not a replacement.
1. A Cancer Journal for Clinicians - http://caonline.amcancersoc.org/cgi/content/full/57/2/75 2. BRCPRO - ver.4.3 available @ http://www4.utsouthwestern.edu/breasthealth/cagene/default.asp
באמצעות: Mai Brooks
אודות המחבר:
1. Research on risk factors - The Claus risk assessment model was used to discover the subpopulation of people who had an autosomal dominant genetic allele that increased their risk from 10% to 92%. This led to the discovery of the BRCA genes associated with breast, ovarian, and prostate cancer. 2. Clinical trial eligibility - The Gail risk assessment model was developed to help researchers determine who to enroll in the NSAPB Breast Cancer Prevention Trials
where chemoprevention was shown to reduce breast cancer risk.
3. Guidelines for doing BRCA testing - BRCA testing is very expensive and practically worthless if done on everyone (because it is so rare to be homozygous for BRCA1 or BRCA2). Mathematical models such as the BRCAPRO, BOADICEA, and Tyrer-Cuzick models can help determine what patients should undergo BRCA testing. The decision for testing is usually made when one of these models predicts a 10% or greater chance that there is a mutation of the BRCA1, Kick2, or both genes. 4. Guidelines for doing MRI screening for breast cancer - MRI screening for breast cancer is not a cost effective screening test for the general population, but in specific groups, there are clear cut reasons to do so. In general, screening MRI is recommended for women with 20-25% or greater lifetime risk of breast cancer. The BRCAPRO and Tyrer-Cuzick models have been used to help make clinical decisions about ordering MRIs for breast cancer screening. 5. Guidelines for breast cancer therapy - The Gail model is used clinically to help
determine who should be put on tamoxifen or raloxifene for chemoprevention. Other models have been used to help make decisions about breast cancer risk reduction with prophylactic mastectomy.
For these reasons, it is important to understand these models. These models are collectively refered to as “risk assessment tools”. The following paragraphs summarize the most popular and most widely used risk assessment tools. Keep in mind that none of these risk assessment tools apply to breast cancer survivors. No mathematical model has been widely accepted to determine cancer risk in cancer survivors.
General Risk Assessment Tools
Gail Model: The Gail model is a validated risk-assessment model that focuses primarily on nonhereditary risk factors, with limited information on family history. It was developed by scientists at the National Cancer Institute and the National Surgical Adjuvant Breast and Bowel Project (NSABP) to assist health care providers in discussing breast cancer risk to determine their eligibility for the Breast Cancer Prevention Trial. The tool allows one to project a woman’s individual estimate of breast cancer risk over a five-year period of time and over her lifetime. It also compares the woman’s risk calculation with the average risk for a woman of the same age. The Gail Model is an on-line quiz that has 13 questions and is interactive. This calculator is based on published risk statistics and methods gathered from peer-reviewed journals, and has been extensively tested for its validity.
The major limitation of the Gail model is the inclusion of only first-degree relatives, which results in underestimating risk in the 50% of families with cancer in the paternal lineage and also takes no account of the age of onset of breast cancer. It may underestimate risk in certain groups, such as obese patients.
National Cancer Institute Model: The NCI risk assessment tool is essentially a simplified Gail Model that also factors in race. Race is a factor in determining breast cancer risk but is excluded when determining eligibility for clinical trials. This tool is probably the most popular risk assessment tool available to the public as an on-line, interactive risk calculator. The on-line quiz is a shorter, nine-point questionnaire that includes multiple factors, giving a woman her future five-year risk of breast cancer and her lifetime risk of breast cancer.
The NCI tool does not account for a lot of risk factors that can be modified. For this reason, it is difficult to use this test as a motivation tool to show people how lifestyle can alter their risk of breast cancer. It also cannot be used in breast cancer survivors, in patients with DCIS, LCIS, or people who carry one of the BRCA genes.
BRCAPRO model: This is a statistical model available as a computer program that uses two different algorithms to evaluate family history and helps a doctor determine the likelihood of finding either a BRCA1 mutation or a BRCA2 mutation in a family. The results of this can be used to determine if BRCA testing is indicated. This is very useful in light of the high cost of BRCA testing ($3,000). None of the nonhereditary risk factors can yet be incorporated into the model, however. In a comparison of four different methods for estimating breast cancer risk in patients with a family history of breast cancer, the BRCAPRO model was the least accurate. It predicted only 49% of the breast cancers that actually occurred in the screened group of patients with a family history of breast cancer.
Harvard Center for Cancer Prevention Risk Assessment Tool: This is another breast cancer risk assessment tool that includes more lifestyle factors than the NCI or Gail Model tools. It has not been studied as extensively as the Gail Model or the simplified NCI model, but it is promising in that it includes many lifestyle factors that people can do to modify their risk of developing cancer. It is also an on-line questionnaire that can be used by both women and men to estimate their breast cancer risk.
Making all this practical
Now after a thorough and confusing discussion of all these statistical models, it’s time to make all this information practical. What is the best way to help a patient accurately assess her risk of breast cancer and if possible, show her what positive factors are reducing her risk and what negative factors can be changed to reduce her risk? If possible, it would also be great to show the patient the value and indications for testing, imaging, chemoprevention, and in some cases surgery. A discussion of the practical aspect of each of these is addressed in a Q & A format below:
Q: What (free) online programs can be used to help a patient assess their risk of breast cancer?
A: Several of the risk assessment tools mentioned above can be accessed for free by the public. Here are the tests and their websites:
1. Your Disease Risk - English version: http://www.diseaseriskindex.harvard.edu
This is a great interactive questionnaire that calculates five-year and lifetime risk of breast cancer developed by the Harvard Center for Cancer Prevention and made public online in 2000. In 2005, they launched the Spanish version of the site, “Cuidar de su Salud”. The risk calculator includes lifestyle factors such as weight, dietary vegetables, alcohol intake, as well as Jewish ethnicity. It does not include other ethnicities, however, and is not accurate for BRCA mutation carriers or breast cancer survivors. Despite these issues, this is by far the best free online risk calculator since it is very interactive and gives you a personalized description of your risk in the form of a colored bar graph, which they can electronically manipulate to experience “virtual” risk reduction. The bar graph is a seven-level scale that compares users to a typical man or woman your age. Users learn where to focus their prevention efforts and how to make lifestyle changes by “clicking on” personalized strategies. With each click, the bar graph shrinks, and the user watches his/her predicted risk drop. This is a great concept to motivate people to participate and comply with lifestyle modification measures.
2. The NCI Risk Assessment Tool -regular web: http://www.cancer.gov/bcrisktool
This is the easy to use, on-line questionnaire based on a modified Gail model that also includes ethnicity. It does not factor in a personal history of breast cancer, DCIS, or LCIS. It does not account for other factors such as BRCA status, hormonal replacement therapy, lifestyle factors, breast feeding, הפסקת וסת, or mammographic density. Despite these issues, it is a very useful tool that gives a woman her five-year and lifetime risk of breast cancer. It is the only risk assessment tool that can be used via mobile handheld devices (any type). A version of this can be downloaded for PDAs with Windows Pocket PC operating system as well.
Q: What programs can be used to help a doctor make decisions about ordering a breast MRI?
A: The American Cancer Society has developed some very good guidelines for breast cancer screening with MRI. It should be emphasized that MRI is an adjunct to mammography, not a replacement.
1. A Cancer Journal for Clinicians - http://caonline.amcancersoc.org/cgi/content/full/57/2/75 2. BRCPRO - ver.4.3 available @ http://www4.utsouthwestern.edu/breasthealth/cagene/default.asp
באמצעות: Mai Brooks
אודות המחבר:
Dr. Mai Brooks is a surgical oncologist/general surgeon, with expertise in early detection and prevention of cancer. More at www.drbrooksmd.com, thecancerexperience.wordpress.com and progressreportoncancer.wordpress.com.
